JASON A. HOFFMAN, PhD jason@jasonhoffman.org EDUCATION PhD in Molecular Pathology (2003), UCSD Committee: Erkki Ruoslahti MD PhD, Chair, Marilyn Farquhar PhD, Co-chair, Web Cavenee PhD, David Cheresh PhD, Ted Friedmann MD and Jeff Smith PhD CPhil in Molecular Pathology (2002), UCSD MSc in Biochemistry (1997), UCLA BSc in Biochemistry (1996), UCLA EXPERIENCE Chief Technical Officer and Founder, Joyent Inc., Dec 2005-present President/Chief Operating Officer and Founder, Strongspace LLC., Jun 2005-Dec 2005 President/Chief Operating Officer and Founder, TextDrive Inc., Jun 2004-Dec 2005 Visiting Lecturer, UCSD Department of Pathology, Sept 1999-Sept 2005 Postdoctoral Associate, Genomics Institute of the Novartis Research Foundation (GNF), Sept 2003-Aug 2004 Visiting Graduate Student, Lab of Erkki Ruoslahti at the Burnham Institute, Sept 1997-Aug 2003 Chief Editor and Principal, SciEdit Inc., Aug 1998-Dec 2003 Master MCAT Trainer, The Princeton Review, Jan 1999-Jun 2005 Senior MCAT Chemistry Instructor, The Princeton Review, Jun 1997-Jun 2005 Consultant, The Burnham Institute and Targeted Molecules Corporation, Nov 2000-Aug 2001 Graduate Student Researcher, UCLA Dept. of Chemistry and Biochemistry, Division of Organic Chemistry, Aug 1996-Jun 1997 Teaching Assistant, UCLA Dept. of Chemistry and Biochemistry, Sept 1996-Jun 1997 Lab Assistant II, UCLA Dept. of Biological Chemistry, May 1995-Aug 1996 CPR Instructor, St. Mary Medical Center, Apr 1991-Jul 1997 Emergency Medical Technician, St. Mary Medical Center Emergency Dept. and Trauma Center, Jan 1991-Jan 1995 SCIENTIFIC PUBLICATIONS Lianglin Zhang, Enrico Giraudo, Jason A. Hoffman, Douglas Hanahan and Erkki Ruoslahti (2006). Lymphatic zip codes in premalignant lesions and tumors. Cancer Res. 2006 Jun 1;66(11):5696-706 Lianglin Zhang*, Jason A. Hoffman*, and Erkki Ruoslahti (2005). Molecular profiling of heart endothelial cells. Circulation. 2005 Sep 13;112(11):1601-11. *Equal contribution cited Jason A. Hoffman, Pirjo Laakkonen, Kimmo Porkka, Michele Bernasconi and Erkki Ruoslahti (2004). In vivo and ex vivo selections using phage-displayed libraries. In Phage Display: A Practical Approach, T. Clackson and H. Lowman, eds. (Oxford, U.K.: Oxford University Press). Jason A. Hoffman, Enrico Giraudo, Mallika Singh, Lianglin Zhang, Masahiro Inoue, Kimmo Porkka, Douglas Hanahan and Erkki Ruoslahti (2003). Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. Cancer Cell, 4(5), 383-391. Pirjo Laakkonen, Kimmo Porkka, Jason A. Hoffman and Erkki Ruoslahti (2002). A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nature Medicine, 8(7), 751-755. Kimmo Porkka, Pirjo Laakkonen, Jason A. Hoffman, Michele Bernasconi and Erkki Ruoslahti (2002). A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo. Proc. Natl. Acad. Sci. 99(11):7444-7449 PATENTS and PATENT APPLICATIONS Pirjo Laakkonen, Jason A. Hoffman, Kimmo Porkka and Erkki Ruoslahti. Peptides that home to tumor lymphatic vasculature and methods of using same Issued US patent 7,192,921 (issue date 3/20/07) Pending US patent application (divisional) 11/712,043 Pending European patent application 02795599.6 Lianglin Zhang, Jason A. Hoffman, Erkki Ruoslahti Peptides that selectively home to heart vasculature and related conjugates and methods Pending US patent application 11/222,370, filed 09/07/05 Pending European patent application 05795216.0 Pending Chinese patent application (no serial number yet) Pending Japanese patent application (no serial number yet) Pirjo Laakkonen, Jason A. Hoffman, Kimmo Porkka and Erkki Ruoslahti. Lymphatic Zip Codes in Tumors and Pre-Malignant Lesions Pending US patent application 11/670,318 Pending PCT patent application PCT/US2007/061480 FELLOWSHIPS and SUPPORT National Cancer Institute Pre-doctoral Training Grant T32 CA77109-05 (1/99-7/03) UC Regents Graduate Fellowship (9/97-1/99) UCLA Teaching Fellow (9/96-6/97) TECHNICAL EXPERIENCE and EXPERTISE Expert technologist and team lead All major techniques in chemistry, biochemistry, molecular biology, immunology, histology and tumor biology. Experienced in high throughput and multiplex techniques. Expert level experience in system's administration and bioinformatics.